Therapeutic agent for alzheimer's disease

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/00 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2654033

Disclosed are a novel therapeutic method and a novel therapeutic agent for the treatment of Alzheimer's disease. Specifically, disclosed are: an antiinflammatory cytokine; an anti-inflammatory cytokine gene; and a negative-strand RNA viral vector carrying an anti-inflammatory cytokine gene, each of which can be used for the treatment of Alzheimer's disease or the development of a therapeutic agent for Alzheimer's disease. Also disclosed is a pharmaceutical composition for the treatment or prevention of Alzheimer's disease, which comprises the cytokine or the vector. Further disclosed is a method for the treatment of Alzheimer's disease, which comprises the step of administering an antiinflammatory cytokine or a vector such as a negative-strand RNA viral vector carrying an antiinflammatory cytokine gene. It becomes possible to provide a novel gene therapy for Alzheimer's disease.

La présente invention concerne un nouveau procédé thérapeutique et un nouvel agent thérapeutique destinés au traitement de la maladie d'Alzheimer. Plus précisément, l'invention concerne : une cytokine anti-inflammatoire ; un gène de cytokine anti-inflammatoire ; et un vecteur viral à ARN à brin négatif portant un gène de cytokine anti-inflammatoire, chacun pouvant être utilisé pour le traitement de la maladie d'Alzheimer ou le développement d'un agent thérapeutique pour la maladie d'Alzheimer. Il est également décrit une composition pharmaceutique destinée au traitement ou à la prévention de la maladie d'Alzheimer, comprenant la cytokine ou le vecteur. Il est en outre décrit un procédé de traitement de la maladie d'Alzheimer comprenant l'étape consistant à administrer une cytokine anti-inflammatoire ou un vecteur, tel qu'un vecteur viral à ARN à brin négatif portant un gène de cytokine anti-inflammatoire. Il devient possible de fournir une nouvelle thérapie génique pour la maladie d'Alzheimer.

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