Therapeutic agent for disorder of lipid metabolism

Details Therapeutic agent for disorder of lipid metabolism Therapeutic agent for disorder of lipid metabolism

A - Human Necessities

61

K

A61K 38/18 (2006.01)

Patent

CA 2184248

The present invention relates to a therapeutic agent for treatment of disorder of lipid metabolism comprising TCF-II as an effective ingredient. The therapeutic agent of the present invention is useful for treatment of disorder of lipid metabolism caused by diabetes, endocrinological diseases, such as thyroid dysfunction and adrenal dysfunction, chronic metabolism disorder, chronic renal failure including nephrosis, uremia, cancer, dyscrasia, adverted effects of antitumor agents, gastrointestinal (including hepatic and pancreatic) impairment and so on. Hypercholesterolemia, hypolipidemia or hypo- high-density-lipoproteinemia is exemplified as a disorder of lipid metabolism. The therapeutic agent of the present invention normalizes not only hyperlipidemia but also hypolipidemia. In addition, it improves fatty liver.

Agent thérapeutique destiné à traiter des troubles du métabolisme des lipides qui comprend TCF-II en tant que principe actif. L'agent thérapeutique de la présente invention est utile pour traiter des troubles du métabolisme des lipides causés par le diabète, les maladies endocriniennes telles que la dysfonction thyroïdienne et la dysfonction surrénale, les troubles métaboliques chroniques, l'insuffisance rénale chronique dont le syndrome néphrotique, l'urémie, le cancer, la dyscrasie, les effets secondaires des agents antitumoraux, les troubles gastro-intestinaux (y compris hépatiques et pancréatiques) etc. L'hypercholestérolémie, l'hypolipidémie ou l'hypolipoprotéinémie à haute densité sont prises comme exemples de troubles du métabolisme des lipides. L'agent thérapeutique de la présente invention normalise non seulement l'hyperlipidémie, mais aussi l'hypolipidémie. De plus, il améliore la stéatose hépatique.

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