Therapeutic agent for liver disease and piperazine derivatives

Details Therapeutic agent for liver disease and piperazine derivatives Therapeutic agent for liver disease and piperazine derivatives

A - Human Necessities

61

K

167/210, 167/223

A61K 31/55 (2006.01) A61K 31/495 (2006.01) C07D 295/21 (2006.01) C07D 317/60 (2006.01) C07H 15/26 (2006.01)

Patent

CA 1326451

THERAPEUTIC AGENT FOR LIVER DISEASE ABSTRACT OF DISCLOSURE A therapeutic agent for liver disease contain- ing as an active ingredient a piperazine derivative having the formula: Image wherein, A represents a phenyl, p-benzoquinonyl or cumarinyl group which may have at least one substituent selected from the group consisting of halogen, alkyl, fluoroalkyl, formyl, alkoxycarbonyl, acyl, hydroxy, alkoxy, acyloxy, glycosyloxy, amino, alkylamino, mercapto, alkylthio and nitro; B represents a single bond or a straight chain alkylene group containing 1-4 carbon atoms which may have at least one substituent selected from the group consisting of alkyl, aryl, aralkyl, hydroxy and oxo; R represents an atom or a group selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, alkyl, cycloalkyl, aralkyl and aryl; and n is 2 or 3, or its pharmaceutically acceptable salt is diclosed.

589290

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