A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/485 (2006.01) A61P 25/04 (2006.01)
Patent
CA 2383146
The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (see formula I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl--1,2,3,4,4a,5,12,12a-octohydro-trans- quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.
Cette invention concerne des remèdes contre les douleurs neuropathiques dont les composés de principe actif sont représentés par la formule générale (I) (dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, A et B sont tels que définis dans le descriptif) ou sont des sels de ces composés acceptables au plan pharmacologique. L'invention porte également sur des modèles animaux préparés par l'administration de (+)-4a-(3-hydroxyphényle)-2-méthyle-1,2,3,4,4a,5,12,12a-octahydro-trans-quinolino[2,3-g]lisoquinoline. Ces remèdes et ces animaux modèles rendent possible le traitement médicamenteux des douleurs neuropathiques et permettent de surcroît d'évaluer les effets thérapeutiques desdits composés sur les douleurs neuropathiques.
Endo Takashi
Kawamura Kuniaki
Kuraishi Yasushi
Nagase Hiroshi
Shiraki Kimiyasu
Smart & Biggar
Toray Industries Inc.
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