A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 17/04 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2708065
The present inventors isolated clone BM095 from a human antibody phage library, which had a strong growth inhibitory activity in the IL-31-dependent Ba/F3 cell growth assay system. When administered to pruritus model mice, the anti-mouse NR10 neutralizing antibody exhibited a marked symptom-suppressing effect. Thus, it was revealed that anti-NR10 neutralizing antibodies are useful as therapeutic agents for pruritus.
La présente invention concerne un clone BM095, tiré d'une banque de phages anticorps humains, présentant une puissante activité inhibitrice de la prolifération dans un système de dosage de la prolifération de cellules Ba/Fc dépendante de IL-31. Lorsque l'anticorps neutralisant anti-NR10 de souris est administré à un modèle animal de prurit, un effet important d'inhibition des symptômes de la maladie est observé. Il est révélé que l'anticorps neutralisant anti-NR10 est utile comme agent thérapeutique contre le prurit.
Hasegawa Masakazu
Higuchi Yoshinobu
Kasutani Keiko
Kitamura Hidetomo
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Chugai Seiyaku Kabushiki Kaisha
LandOfFree
Therapeutic agent for pruritus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Therapeutic agent for pruritus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic agent for pruritus will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1370882