Therapeutic agent for sepsis

Details Therapeutic agent for sepsis Therapeutic agent for sepsis

A - Human Necessities

61

K

A61K 38/07 (2006.01) A61K 31/40 (2006.01) A61K 31/485 (2006.01) A61P 31/02 (2006.01)

Patent

CA 2451133

Remedies for sepsis and symptoms associating sepsis (septic shock, disseminated intravascular coagulation syndrome, adult respiratory distress syndrome, multiorgan function failure, etc.). These remedies contain as the active ingredient opioid .kappa. receptor agonistic compounds such as (-)-17- (cyclopropylmethyl)-3,14.szlig.-dihydroxy-4,5a-epoxy-6.szlig. [N-methyl-trans- 3-(3-furyl)acrylamido]morphinan hydrochloride. These opioid .kappa. receptor agonistic compounds may be orally or parenterally administered either as such or as in the form of medicinal compositions prepared by mixing with publicly known pharmacologically acceptable acids, carriers, excipients, etc.

L'invention concerne des remèdes contre la sepsie et les symptômes afférents (choc septique, syndrome de la coagulation intravasculaire disséminée, syndrome de la détresse respiratoire adulte, dysfonctionnement de plusieurs organes, etc.). Ces remèdes contiennent, comme ingrédient actif, des composés d'agonistes du récepteur K opioïde, tels que (-)-17-(cyclopropylméthyl)-3,14.beta.-dihydroxy-4,5.alpha.-époxy-6.beta.[N-méthyl-trans-3-(3-furyl)acrylamido]morphinan chlorhydrate. On peut administrer par voie orale ou parentérale ces composés d'agonistes du récepteur K opioïde, en tant que tels ou sous forme de compositions médicinales préparées par mélange d'excipients, de porteurs, d'acides connus acceptables en pharmacologie etc.

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