Therapeutic agent for the treatment of xerostomia

Details Therapeutic agent for the treatment of xerostomia Therapeutic agent for the treatment of xerostomia

A - Human Necessities

61

K

A61K 31/435 (2006.01)

Patent

CA 2152420

A therapeutic agent for the treatment of xerostomia compris- ing a derivative of spirooxathiolane-quinuclidine or an acid addition salt thereof as an active ingreient represented in the following formula [I]: Image [I] (wherein R1 and R2 may be the same or different and each repre- sents hydrogen, alkyl, cyclopentyl, cyclohexyl, aryl, diaryl- methylol, or alkyl which may be substituted by one or more aryl groups). The above therapeutic agent can be administered orally or parentally and cure xerostomia. Specifically, the agent can be used for improving and/or curing dry mouth caused by various diseases with organic changes in salivary gland, lesions in salivary gland accompanied with systemic diseases, necrosis of saivary gland cell by radiotherapy, HIV infection (AIDS), hypo- function of saliva secretion, affection of various medicines taken and, further, mental fatigue or bad conditions due to com- plex social life situations.

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