C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/18 (2006.01) A61K 31/47 (2006.01) C07D 217/04 (2006.01) C07D 217/20 (2006.01) C07D 405/08 (2006.01)
Patent
CA 2126308
2126308 9313073 PCTABS00024 Tetrahydroisoquinoline compounds of formula (I) and pharmaceutically acceptable salts thereof, in which: R1 represents one or more substituents selected from H, halo, hydroxy, alkyl (optionally substituted by hydroxy), alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, nitro, cyano, polyhaloalkyl, polyhaloalkoxy, phenyl (optionally substituted by one or more of halo, alkyl or alkoxy), or R1 is optionally alkylated carbamoyl; R2 represents an aliphatic group optionally substituted by hydroxy or alkoxy; E represents an alkylene chain optionally substitued by one or more alkyl groups; and G represents phenyl or phenyl substituted by one or more of alkyl, alkoxy, halo, hydroxy, polyhaloalkyl, polyhaloalkoxy, cyano, alkylthio, alkylsulphinyl, alkylsulphonyl, phenyl (optionally substituted by one or more of halo, alkyl or alkoxy), optionally alkylated carbamoyl, or G represents a phenyl ring having fused thereto a heterocyclic or aromatic carbocyclic ring; and O^_-acylated derivatives thereof which provide lipophilic esters have utility in analgesia and in the treatment of psychoses (e.g. schizophrenia), Parkinson's disease, Lesch-Nyan syndrome, attention deficit disorder or cognitive impairment or in the relief of drug dependence or tardive dyskinesia.
Kozlik Antonin
Needham Patricia Lesley
Sargent Bruce Jeremy
Mccarthy Tetrault Llp
The Boots Company Plc
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