Therapeutic agents

Details Therapeutic agents Therapeutic agents

C - Chemistry, Metallurgy

07

D

167/179, 260/294

C07D 295/00 (2006.01) C07C 29/147 (2006.01) C07C 33/50 (2006.01) C07C 45/00 (2006.01) C07C 45/42 (2006.01) C07C 45/44 (2006.01) C07C 49/237 (2006.01) C07C 49/567 (2006.01) C07C 57/46 (2006.01) C07C 61/40 (2006.01) C07D 211/70 (2006.01) C07D 295/073 (2006.01) C07D 295/185 (2006.01)

Patent

CA 1248955

Abstract Compounds of formula I Image in which n=0 or 1; R1 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C3-6 cycloalkylalkyl or optionally substituted phenyl when n = 0 or R1 is H or C1-3 alkyl when n = 1, R2 is H or C1-3 alkyl, R3 and/or R4 are H, formyl, C1-3 alkyl, C3-6 alkenyl, C3-6 alkynyl, C3-7 cycloalkyl or R3 and R4 together with the nitrogen atom form a heterocyclic ring system; R5 and/or R6 are H, halo, CF3, C1-3 alkyl, C1-3 alkoxy, C1-3 alkylthio or R5 and R6 together with the carbon atoms to which they are attached form a second benzene ring and R7 and/or R8 are H or C1-3 alkyl show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are dis- closed.

400146

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