Therapeutic agents and autoimmune diseases

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 14/245 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2225788

There is disclosed the use, as an agent in the treatment or the prevention of an autoimmune disease, of: (i) an agent having GM-1 binding activity, other than Ctx or Etx, or the B subunits of Ctx and Etx; or (ii) an agent having an effect on GM-1 mediated intracellular signalling events, but no GM-1 binding activity. These agents may also be used in the treatment of human T cell leukaemia, in the prevention of transplant rejection or GVHD or in a vaccination method for vaccinating a mammalian subject.

L'invention concerne l'utilisation des agents suivants dans le traitement ou la prévention d'une maladie auto-immune : i) un agent pouvant se lier à GM-1, autre que Ctx ou Etx, ou les sous-unités B de Ctx et d'Etx; ou ii) un agent ayant un effet sur la signalisation intracellulaire liée à GM-1 mais ne pouvant se lier à GM-1. Ces agents peuvent également être utilisés pour traiter les leucémies à lymphocytes T chez l'humain, pour prévenir le rejet pouvant survenir après une greffe ou la réaction du greffon contre l'hôte, ou encore pour la vaccination de mammifères.

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