A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/498 (2006.01) A61K 31/517 (2006.01) A61K 45/06 (2006.01) A61P 9/12 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2519930
The invention relates to the use of an anti-angiogenic agent in combination with an inhibitor of the Src family of non-receptor tyrosine kinases in the manufacture of a medicament for use in the substantially normotensive treatment in a warm-blooded mammal such as a human being of a disease state associated with angiogenesis, the Src kinase inhibitor being administered in an amount effective to counteract substantially the hypertension induced by the anti-angiogenic agent.
L'invention concerne l'utilisation d'un agent anti-angiogénique associé à un inhibiteur de la famille Src des tyrosine kinases non réceptrices, dans la fabrication d'un médicament destiné à être utilisé dans un traitement sensiblement normotensif, chez un mammifère à sang chaud, tel qu'un être humain, dont l'état pathologique est lié à l'angiogenèse. L'inhibiteur des kinases Src est administré dans une quantité efficace pour compenser sensiblement l'hypertension induite par l'agent anti-angiogénique.
Curwen Jon Owen
Wedge Stephen Robert
Astrazeneca Ab
Fetherstonhaugh & Co.
LandOfFree
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