C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/78 (2006.01) A61K 38/26 (2006.01) A61K 38/28 (2006.01) A61K 38/48 (2006.01) A61K 47/48 (2006.01) A61P 3/08 (2006.01) A61P 7/04 (2006.01) C07K 14/605 (2006.01) C07K 14/62 (2006.01) C07K 19/00 (2006.01) C12N 9/64 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2726894
The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistance in the body, solubility, and bioavailability.
La présente invention porte sur des agents thérapeutiques et sur des compositions comprenant des peptides de type élastine (ELP) et des protéines thérapeutiques. Dans certains modes de réalisation, la protéine thérapeutique est un agoniste du récepteur GLP-1, de l'insuline, ou un facteur VII/VIIa, comprenant les analogues fonctionnels. La présente invention porte en outre sur des polynucléotides codants, ainsi que sur des procédés de production et d'utilisation des agents thérapeutiques. Les agents thérapeutiques ont des améliorations concernant leur utilisation en tant que produits thérapeutiques, comprenant, entre autres, au moins l'une parmi la demi-vie, la clairance et/ou la persistance dans le corps, la solubilité et la biodisponibilité.
Deeth Williams Wall Llp
Duke University
LandOfFree
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