Therapeutic agents for hyperammonemia

Details Therapeutic agents for hyperammonemia Therapeutic agents for hyperammonemia

A - Human Necessities

61

K

A61K 31/7016 (2006.01) A61K 31/70 (2006.01) A61K 31/702 (2006.01) A61P 1/16 (2006.01) A61P 3/00 (2006.01) C07H 3/04 (2006.01)

Patent

CA 2353865

By using xylobiose or xylooligosaccharide containing xylobiose as a main ingredient in place of lactulose, there is provided a blood ammonia lowering agent, a therapeutic agent of hyperammonemia or a therapeutic agent of hepatic encephalopathy that need be adminstered in smaller doses and which have no concern over side effects. Lactulose conventionally used as such drugs has to be administered in high doses and involves a safety problem when administered to patients with galactosemia or diabetes mellitus. The drug of the invention which contains xylobiose as a main ingredient solves these problems.

L'invention concerne des agents de réduction de la teneur en ammoniaque du sang, des remèdes contre l'hyperammoniémie ou des remèdes contre l'encéphalopathie hépatique, sans risque d'effets secondaires, dans lesquels du xylobiose en tant que composant principal est utilisé comme substitut du lactulose, de manière que la dose administrer soit réduite. Le lactulose, qui a été employé jusqu'à maintenant dans les médicaments, doit être administré en dose importante et pose des problèmes lorsqu'il est administré à des patients souffrant de galactosémie ou de diabète. Ces problèmes peuvent être résolus au moyen des médicaments de l'invention, lesquels contiennent du xylobiose comme composant principal.

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