Therapeutic agents for opthalmopathy

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) A61K 38/18 (2006.01) A61K 38/20 (2006.01) A61K 45/00 (2006.01) A61P 9/10 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01) C07K 16/24 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2398900

Remedies for ophthalmic diseases such as glaucoma and retinal diseases. Compounds having an interleukin-1 inhibitory activity (for example, endogenous interleukin-1 receptor antagonist proteins, interleukin-1 neutralizing antibodies) have remarkable effects of inhibiting a decrease in the cell count in retinal ganglial cell layer, preventing entoretinal layer from thinning, and lowering ocular tension.

L'invention se rapporte à des remèdes pour troubles ophtalmiques tels que le glaucome et les affections rétiniennes. Les composés présentant une activité d'inhibition de l'interleukine-1 (les protéines antagonistes des récepteurs de l'interleukine-1 endogènes, les anticorps neutralisant l'interleukine-1) présentent des effets remarquables s'agissant d'inhiber la réduction du nombre de cellules dans la couche des cellules ganglionnaires de la rétine, d'empêcher l'amincissement de la couche endorétinienne et d'abaisser la tension oculaire.

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