Therapeutic agents for the treatment of multidrug resistance...

A - Human Necessities – 61 – K

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A61K 31/49 (2006.01) A61K 9/127 (2006.01) A61K 9/14 (2006.01) A61K 9/50 (2006.01) A61K 31/495 (2006.01) A61K 31/54 (2006.01) A61K 31/545 (2006.01) A61K 31/55 (2006.01) A61K 31/57 (2006.01) A61K 38/13 (2006.01)

Patent

CA 2081343

Cinchonine, dihydrocinchonine or hydroquinidine are used as multidrug resistance inhibiting substance in the treatment of cancerous tumors by the use of cytotoxic agents. Particularly, cinchonine, dihydrocinchonine or hydroquinidine are used in the preparation of pharmaceutical compositions used in the treatment of cancerous tumors developping the phenomenon of multidrug resistance. Application to the treatment of human cancers.

On utilise de la cinchonine, dihydrocinchonine ou hydroquinidine à titre de substance inhibitrice de la résistance multidro- gue dans le traitement de tumeurs cancéreuses au moyen d'agents cytotoxiques. En particulier on utilise la cinchonine, la dihydro- cinchonine ou l'hydroquinidine dans la préparation de compositions pharmaceutiques destinées au traitement de tumeurs cancé- reuses développant le phénomène de résistance multidrogue. Application au traitement des cancers chez l'homme.

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