A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/64 (2006.01) A61K 31/00 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/549 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2583397
The present invention is directed to therapeutic compositions targeting the NCCa-ATP channel of an astrocyte, neuron or capillary endothelial cell and methods of using same. More specifically, agonists and antagonists of the NCCa- ATP channel are contemplated. The therapeutic compositions are used to treat cancer, more specifically, a metastatic brain tumor, wherein a tumor-brain barrier is present. Such treatments are contemplated in combination with conventional anti-cancer therapies. Alternatively, the compositions are used to prevent cell death and to treat cerebral edema that result from ischemia, due to interruption of blood flow, to tissue trauma or to increased tissue pressure.
L'invention concerne des compositions thérapeutiques ciblant le canal NCCa-ATP d'un astrocyte, d'un neurone ou d'une cellule endothéliale capillaire et leurs méthodes d'utilisation. L'invention concerne, plus spécifiquement, des agonistes et des antagonistes du canal NCCa-ATP. Lesdites compositions thérapeutiques sont utilisées pour traiter le cancer, et plus spécifiquement, une tumeur cérébrale métastatique dans laquelle une barrière tumeur-cerveau est présente. Ces traitements sont administrés en association avec des thérapies anticancéreuses classiques. Dans un autre mode de réalisation, ces compositions sont utilisées pour empêcher la mort cellulaire et pour traiter un oedème cérébral résultant d'une ischémie provoquée par l'interruption du flux sanguin, un traumatisme tissulaire ou une pression tissulaire accrue.
Chen Mingkui
Simard J. Marc
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The United States Of America As Represented By The Department Of
University Of Maryland Baltimore
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