Therapeutic and diagnostic agents

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2507709

The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides molecules having structural features characteristic of immunoregulatory signalling (IRS) molecules and which are expressed by cells of haematopoietic lineages such as, in particular, leukocytes. The molecules of the present invention find broad application inter alia as diagnostic markers for cells, targets for cell therapy and as validated drug targets in order to modulate the immune response and to treat, prevent and diagnose a range of diseases conditions including cancer, genetic disease, inflammatory conditions and conditions associated with aberrant haematopoietic cell function or activity. The present invention extends to binding partners of the instant molecules such as, for example, antibodies, ligands, adaptor and other signalling associated molecules, agonists and antagonists and to methods of screening for same.

La présente invention concerne d'une façon générale des agents diagnostiques et thérapeutiques. Cette invention concerne, plus particulièrement, des molécules possédant des particularités structurelles caractéristiques des molécules de signalisation de l'immunorégulation (IRS) et qui sont exprimées par des cellules de lignées hématopoïétiques, telles que, en particulier, des leucocytes. Les molécules de cette invention trouvent une grande application, entre autres choses, comme marqueurs de diagnostic de cellules, comme cibles de thérapie cellulaire et comme cibles de médicament validé de façon à moduler la réponse immune et à traiter, prévenir et diagnostiquer une gamme de maladies comprenant le cancer, une maladie génétique, des états inflammatoires et des états associés à la fonction ou à l'activité de cellules hématopoïétiques aberrante. Cette invention concerne aussi des partenaires de liaison de ces molécules tels que, par exemple, des anticorps, des ligands, un adaptateur et d'autres molécules associées à la signalisation, des agonistes et des antagonistes et des techniques de recherche de ces éléments.

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