A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/7088 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2731416
The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of CXCR-4 in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for CXCR-4. Further, the present invention relates, in part, to the Applicants' surprising discovery that the inhibition of CXCR-4 gene expression or the inhibition of CXCR-4 activity in transformed cells reverses the transformed phenotype.
Boynton Alton L.
Murphy Gerald P.
Sehgal Anil
Fetherstonhaugh & Co.
Northwest Biotherapeutics Inc.
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