Therapeutic and diagnostic compounds, compositions, and methods

Details Therapeutic and diagnostic compounds, compositions, and methods Therapeutic and diagnostic compounds, compositions, and methods

C - Chemistry, Metallurgy

07

F

C07F 9/6524 (2006.01) A61K 51/04 (2006.01) A61P 19/00 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2434302

The invention provides a complex comprising a) a compound formula I: wherein R1, X and n have any of the values described in the specification, or a pharmaceutically acceptable salt thereof; and b) a radionuclide. The complexes are useful as diagnostic agents and as therapeutic agents. The invention also provides methods and intermediates useful for preparing the complexes of the invention, as well as therapeutic and diagnostic methods.

L'invention concerne un complexe comportant a) un composé de formule I, dans laquelle R¿1?, X et n représentent n'importe quelle valeur définie dans la description, ou un sel pharmaceutiquement acceptable de celui-ci; et b) un radionucléide. Ces complexes sont utiles en tant qu'agents diagnostiques et agents thérapeutiques. L'invention concerne également des procédés et des intermédiaires utiles dans la préparation desdits complexes, ainsi que des méthodes diagnostiques et thérapeutiques.

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