C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07D 295/185 (2006.01) C07K 14/47 (2006.01) C07K 14/775 (2006.01) C12N 15/62 (2006.01) G01N 33/564 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2329942
The present invention provides domain 1 .beta.2GPI polypeptides, polynucleotides encoding these polypeptides, mimetics of these polypeptides, and methods using domain 1 .beta.2GPI polypeptides and mimetics. Domain 1 of .beta.2GPI has been shown to bind to anti-cardiolipin (.beta.2GPI-dependent antiphospholipid) antibodies, which are associated with several pathologies, such as thrombosis and fetal loss. The domain 1 .beta.2GPI polypeptides may be used to detect .beta.2GPI-dependent antiphospholipid antibodies in a sample. The invention further provides methods of inducing tolerance using these domain 1 .beta.2GPI polypeptides.
L'invention concerne des polypeptides .beta.¿2?GPI de domaine 1, des polynucléotides codant ces polypeptides, des mimétiques de ces polypeptides et des procédés utilisant des polypeptides et des mimétiques .beta.¿2?GPI de domaine 1. On a trouvé que le domaine 1 des polypeptides .beta.¿2?GPI se lie aux anticorps anti-cardiolipine (anti-phospholipide dépendant de .beta.¿2?GPI), liés à plusieurs pathologies telles que la thrombose et la perte du foetus. On peut utiliser les polypeptides .beta.¿2?GPI de domaine 1 pour détecter dans un échantillon les anticorps anti-phospholipides dépendants de .beta.¿2?GPI. L'invention concerne en outre des procédés pour induire la tolérance en utilisant ces polypeptides .beta.¿2?GPI de domaine 1.
Iverson Gilbert M.
Jones David S.
Linnik Matthew D.
Marquis David M.
Victoria Edward J.
Borden Ladner Gervais Llp
La Jolla Pharmaceutical Company
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