C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2256481
This invention relates to therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids, and on the role of their signaling pathway in endothelial cell migration and/or differentiation. In addition, this invention provides a substantially purified Jagged protein, as well as a substantially purified nucleic acid molecule or segment thereof encoding Jagged protein, or a functionally equivalent derivative, or allelic or species variant thereof.
La présente invention concerne des procédés et compositions thérapeutiques et diagnostiques obtenues à partir de protéines Jagged/Notch et d'acides nucléiques, et leur rôle comme indicateurs de voie dans la migration et/ou différentiation des cellules endothéliales. L'invention concerne en outre une protéine Jagged considérablement purifiée, ainsi qu'une molécule d'acide nucléique considérablement purifiée ou un segment de ladite molécule codant la protéine Jagged, ou un dérivé équivalent du point de vue fonctionnel ou un allèle ou variant dudit dérivé.
Maciag Thomas
Montesano Roberto
Pepper Michael S.
Wong Michael K. K.
Zimrin Ann B.
Gowling Lafleur Henderson Llp
The National American Red Cross
Universite de Geneve
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