C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 15/62 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2145778
The present invention relates to therapeutic and diagnostic methods and compositions based on Notch proteins and nuc- leic acids. Figure 17 displays the sequences of human Notch DNA and the encoded human Notch protein. The invention pro- vides for treatment of disorders of cell fate or differentiation by administration of a therapeutic compound of the invention. Such therapeutic compounds (termed herein "Therapeutics") include Notch proteins and analogs and derivatives (including frag- ments) thereof, antibodies thereto, nucleic acids encoding the Notch proteins, analogs, or derivatives, Notch antisense nucleic ac- ids, as well as toporythmic proteins and derivatives which bind to or otherwise interact with Notch proteins, their encoding nuc- leic acids or antibodies. In a preferred embodiment, a Therapeutic of the invention is administered to treat a cancerous condition, or to prevent progression from a pre-neoplastic or non-malignant state into a neoplastic or a malignant state.
Artavanis-Tsakonas Spyridon
Blaumueller Christine Marie
Fehon Richard Grant
Zagouras Panayiotis
Osler Hoskin & Harcourt Llp
Yale University
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