C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/02 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 14/71 (2006.01) A61K 38/00 (2006.01) A61K 49/02 (1990.01)
Patent
CA 2137799
The present invention relates to neurotrophin-4 (NT-4), a newly characterized member of the BDNF/NGF/NT-3 gene family. The present invention provides for nucleic acid molecules encoding NT-4. Such molecules may comprise a sequence sub- stantially as set forth for NT-4 in the figure [SEQ ID NO:1 (NT-4, viper)]. The present invention provides for therapeutic and di- agnostic methods based on human NT-4 expression, specifically the potential to treat motor neuron diseases and prostate local- ized diseases, immunological related neuromuscular disorders, and peripheral and central nervous system disorders including Alzheimer's disease, Parkinson's disease and Huntington's chorea and epilepsy.
Altar Charles A.
Distefano Peter
Ip Nancy
Ventimiglia Roseann
Wiegand Stanley
Osler Hoskin & Harcourt Llp
Regeneron Pharmaceuticals Inc.
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