C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) C12N 5/095 (2010.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 51/10 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) C40B 40/08 (2006.01) C40B 40/10 (2006.01) G01N 33/48 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2743464
Genes that are deregulated in cancer stem cells (e.g., melanoma stem cells) are disclosed. Methods which involve involve modulating (e.g., inducing, inhibiting, etc.) the activity of the cancer stem cell associated genes are used to treat individuals having melanoma. Cell surface genes that are upregulated in melanoma stem cells are targeted for the selective isolation, detection, and killing of cancer stem cells in melanoma.
La présente invention porte sur des gènes présentant une dérégulation dans des cellules souches cancéreuses (par exemple des cellules souches de mélanome). L'invention concerne également des méthodes de traitement de patients souffrant d'un mélanome,lesdites méthodes impliquent une modulation (notamment, une induction, une inhibition, etc.) de l'activité des gènes associés aux cellules souches cancéreuses. Des gènes de surface cellulaire qui sont régulés à la hausse dans les cellules souches de mélanome sont ciblés en vue de l'isolement, de la détection, et de la destruction sélectifs de cellules souches cancéreuses présentes dans le mélanome.
Frank Markus H.
Frank Natasha Y.
Cassan Maclean
Children's Medical Center Corporation
The Brigham And Women's Hospital Inc.
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