C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 9/16 (2006.01) C12Q 1/42 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2353997
Cellular sensitivity to DNA damaging agents and progression through cell cycle is modulated through manipulation of T cell protein tyrosine phosphatase (TC-PTP) activity. Phenotypic characterization of cells lacking TG-PTP demonstrates a defective progression through the cell cycle, and sensitivity to DNA damaging agents. Screening assays are provided for selecting agents that affect the activity of TC-PTP, including assays relating to the interaction of TC-PTP with its substrate, p62d.
La sensibilité cellulaire aux agents de dégradation de l'ADN et leur progression à travers le cycle cellulaire sont modulés par la manipulation de l'activité de la protéine tyrosine phosphatase lymphocyte T (TC-PTP). La caractérisation phénotypique du manque de cellules TC-PTP met en évidence une progression défectueuse à travers le cycle cellulaire et une sensibilité aux agents de dégradation de l'ADN. Des analyses de criblage permettent de sélectionner des agents qui affectent l'activité de la TC-PTP, comprenant des analyses concernant l'interaction de la TC-PTP avec son substrat, p62dok.
Ibarra Sanchez Maria de Jesus
Simoncic Paul Daniel
Tremblay Michel
Fetherstonhaugh & Co.
Ibarra Sanchez Maria de Jesus
Simoncic Paul Daniel
Tremblay Michel
University Mcgill
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