A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/21 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) C07K 14/16 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2083949
2083949 9217590 PCTABS00016 This invention relates to conjugates of peptides with amino acid sequences similar to the gp120 PND of HIV and carriers which enhance immunogenicity, such conjugates to be used in vaccines for the treatment and transmission prevention of HIV. After vaccination with the conjugates, antibody-containing fluid is extracted from individuals and assessed in an antigen-limited ELISA which contains a thimerosal-containing diluent and selects for high affinity/avidity neutralizing and/or protective HIV-specific antibodies. The conjugates which have induced the production of such antibodies are useful in the treatment and transmission prevention of HIV.
Bloom Barry R.
Cryz Stanley
Devash Yair
Rubinstein Ayre
Albert Einstein College Of Medicine Of Yeshiva University
Blake Cassels & Graydon Llp
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