Therapeutic and prophylactic agents for peptic ulcer

Details Therapeutic and prophylactic agents for peptic ulcer Therapeutic and prophylactic agents for peptic ulcer

C - Chemistry, Metallurgy

07

C

195/129, 167/179

C07C 49/24 (2006.01) C07C 49/743 (2006.01) C07H 3/00 (2006.01) C07H 15/18 (2006.01) C07H 15/203 (2006.01) C07H 15/207 (2006.01)

Patent

CA 1290328

ABSTRACT OF THE DISCLOSURE A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): (I) Image wherein R1 represents hydrogen or =O; R2 represents hydrogen or -OR5; R3 represents hydrogen or -OR6; R4 represents OR7 in the case of the absence of double bond, R5 R6 and R7 each represents hydrogen or an organic residue; X represents group (A): ?C?CH?COR8 (A) or group (B): Image (B) wherein R8 represents alkyl, and R9 and R10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R1 and R3 both represent hydrogen, R2 represents -OR5,R4 represents OR7 and the bond between the carbon atom to which X is attached and the carbon atom to which R4 is attached is a single bond, and when X represents group (B), then R1 represents =O, R2 represents hydrogen, R3 represents -OR6 and the bond between the carbon atom to which X is attached and the carbon atom to which R4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II): Image (II) wherein R11 represents hydrogen or an organic residue, and R12, R13 and R14 each represents an organic residue, or a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.

509985

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