Therapeutic antiangiogenic endostatin compositions

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2348774

Endostatin compositions capable of inhibiting endothelial cell proliferation, inhibiting angiogenesis and causing tumor regression are described. Specifically, amino acid sequences of endostatin proteins and nucleic acid sequences coding for endostatin proteins are provided.

La présente invention concerne des compositions d'endostatine inhibitrices de prolifération cellulaire endothéliale, d'angiogénèse et capables de provoquer une régression de tumeur. L'invention concerne spécifiquement des séquences d'acides aminés de protéines d'endostatine et des séquences d'acides nucléiques codant pour des protéines d'endostatine.

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