Therapeutic antibodies

Details Therapeutic antibodies Therapeutic antibodies

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2423850

A pharmaceutical comprising a therapeutic protein that binds to a therapeutic target, the protein being modified with a compound that inhibits binding of the protein to the therapeutic target, the modified protein being effective for reducing an immune response against the protein and for producing a therapeutic effect by binding to the therapeutic target. The therapeutic protein may be an antibody that includes an antibody combining site that binds to the therapeutic target.

L'invention concerne un agent pharmaceutique renfermant une protéine thérapeutique qui se lie à une cible thérapeutique, ladite protéine étant modifiée avec un composé qui inhibe la liaison de la protéine à la cible thérapeutique. La protéine modifiée s'avère efficace dans la diminution d'une réponse immunitaire vis-à-vis de la protéine et dans la production d'un effet thérapeutique par le biais de la liaison à la cible thérapeutique. La protéine thérapeutique peut être un anticorps comprenant un site de combinaison d'anticorps qui se lie à la cible thérapeutique.

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