Therapeutic antibody purification method and method of use

Details Therapeutic antibody purification method and method of use Therapeutic antibody purification method and method of use

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61P 25/28 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2696417

A method of preparing anti-b amyloid immunoglobulin involves treating human plasma anti-b amyloid immunoglobulin under alkaline conditions, such as at pH 10.25 to 11.75 using diethylamine HCl, to dissociate b amyloid protein therefrom. Typically, the anti-b amyloid immunoglobulin is present in human immunoglobulin preparations obtained from plasma or serum. Anti-b amyloid immunoglobulin prepared by the method is substantially free of b amyloid protein and has therapeutic activity in compositions and/or methods for treating a disease or condition associated with b amyloid plaques, such as Alzheimer's disease.

L'invention concerne un procédé de préparation d'une immunoglobuline anti-amyloïde b met en jeu le traitement d'une immunoglobuline anti-amyloïde b du plasma humain dans des conditions alcalines, telles qu'à un pH de 10,25 à 11,75 à l'aide de diéthylamine HCl, pour dissocier la protéine amyloïde b à partir de celle-ci. Typiquement, l'immunoglobuline anti-amyloïde b est présente dans des préparations d'immunoglobuline humaine obtenues à partir de plasma ou de sérum. Une immunoglobuline anti-amyloïde b préparée par le procédé est sensiblement exempte de protéine amyloïde b et possède une activité thérapeutique dans des compositions et/ou procédés pour traiter une maladie ou un état associé à des plaques d'amyloïde b, comme la maladie d'Alzheimer.

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