A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7088 (2006.01) A61K 31/7125 (2006.01) A61P 1/00 (2006.01) C12N 15/113 (2010.01) C07H 21/04 (2006.01)
Patent
CA 2589650
Disclosed herein is a method for the sustained amelioration and/or treatment of ulcerative colitis comprising rectal administration of a compound comprising an antisense oligonucleotide having the sequence 5'- GCCCAAGCTGGCATCCGTCA-3', ISIS 2302. The method results in a decrease in the indications of ulcerative colitis for an extended period (greater than 90 days) after the conclusion of the administration of the composition. The composition is well tolerated and systemic exposure is minimal.
L'invention concerne une méthode permettant de soulager et/ou de traiter de façon prolongée la rectocolite hémorragique, consistant en l'administration rectale d'un composé comprenant un oligonucléotide antisens présentant la séquence 5'-GCCCAAGCTGGCATCCGTCA-3', ISIS 2302. La méthode entraîne une diminution des signes de la rectocolite hémorragique sur une durée prolongée (supérieure à 90 jours) après l'arrêt de l'administration de la composition. La composition est bien tolérée est l'exposition systémique est minime.
Atlantic Pharmaceuticals Limited
Isis Pharmaceuticals Inc.
Smart & Biggar
LandOfFree
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