Therapeutic applications of chimeric organogenesis

Details Therapeutic applications of chimeric organogenesis Therapeutic applications of chimeric organogenesis

A - Human Necessities

61

K

A61K 35/36 (2006.01) A61L 27/00 (2006.01) A61L 27/38 (2006.01) A61L 27/60 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2154368

A process for culturing and generating a chimeric cell culture, in particular chimeric epithelium, is disclosed. The chimeric epithelium oan be used to treat skin trauma such as burn victims. Autologous epithelial grafts have been used on burn patients although this requires that the patient's cells are cultured and expanded in vitro which generally takes four to five weeks. The chimeric epithelium of the present invention is composed of cells that are both autologous and allogeneic to the host. Therefore, the allogeneic cells can be maintained in a cell bank and co--cultured with autologous host cells when needed. This significantly reduces the time required (by up to 50 %) for autologous cell expansion and culture prior to grafting. Furthermore, it has been demonstrated that the allogeneic cells are passively eliminated from the graft without rejection of the total graft.

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