C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) A61K 35/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2324517
Mature FLINT protein (mFLINT) binds FasL and LIGHT, and prevents FasL-Fas interaction. mFLINT inhibits FasL-Fas-mediated apoptotic and proinflammatory activity, and is useful in treating disorders associated with abnormal apoptosis and inflammation. The invention provides the amino acid and nucleotide sequences of FLINT and mature FLINT. The preparation and characterization of transgenic animals that express FLINT is disclosed. Therapeutic compositions and methods of treatment utilizing mFLINT are also provided.
La protéine FLINT mûre (mFLINT) lie FasL et LIGHT et fait obstacle à l'interaction FasL-Fas. mFLINT inhibe l'activité apoptotique et proinflammatoire induite par l'interaction FasL-Fas, et se révèle utile dans le traitement de troubles associés à une apoptose ou une inflammation anormales. On décrit les séquences aminoacides et nucléotidiques de FLINT et de la protéine FLINT mûre, ainsi que la préparation et la caractérisation d'animaux transgéniques exprimant FLINT. On décrit enfin des compositions thérapeutiques et des procédés de traitement mettant en oeuvre mFLINT.
Bumol Thomas Frank
Dou Shenshen
Glasebrook Andrew Lawrence
Gould Kenneth Elliot
Hale John Edward
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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