C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7105 (2006.01) A61K 31/711 (2006.01) A61K 31/713 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2705488
The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
La présente invention concerne des procédés et des compositions pour moduler la sénescence cellulaire et la prolifération cellulaire avec des isoformes de la protéine suppresseur de tumeur p53. Les procédés et les compositions de l'invention sont utiles pour inhiber la croissance cellulaire cancéreuse ou pour générer des populations de cellules à des fins de régénération tissulaire par modulation de la sénescence et de la prolifération cellulaires.
Bourdon Jean-Christophe
Fujita Kaori
Harris Curtis C.
Horikawa Izumi
Lane David P.
Smart & Biggar
The Government Of The United States Of America As Represented By
Vojtesek Borivoj
LandOfFree
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