A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/554 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2259962
Activation by CD40 ligand (CD40L) of smooth muscle cells bearing CD40 on the surface of the cells is inhibited in vivo and ex vivo by contacting the cells with an agent capable of inhibiting interaction between CD40L and CD40 on the cells. In vivo inhibition of CD40-bearing smooth muscle cells is used to treat smooth muscle cell-dependent diseases.
L'activation par le ligand CD40 (CD40L) des cellules des muscles lisses porteuses de CD40 sur la surface des cellules est inhibée in vivo et ex vivo pour la mise en contact des cellules avec un agent pouvant inhiber l'interaction entre CD40L et CD40 sur les cellules. L'inhibition in vivo des cellules des muscles lisses porteuses de CD40 permet de traiter les maladies dépendantes des cellules des muscles lisses.
Chess Leonard
Karpusas Mihail N.
Lederman Seth
Thomas David W.
Yellin Michael J.
Biogen Inc.
Biogen Idec Ma Inc.
Smart & Biggar
The Trustees Of Columbia University In The City Of New York
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