Therapeutic binding molecules

Details Therapeutic binding molecules Therapeutic binding molecules

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C12N 15/79 (2006.01)

Patent

CA 2537217

A molecule comprising at least one antigen binding site, comprising in sequence the hypervariable regions CDR1, CDR2 and CDR3, said CDR1 having the amino acid sequence Asn-Tyr-Ile-IIe-His (NYIIH), said CDR2 having the amino acid sequence Tyr-Phe-Asn-Pro~Tyr-Asn-His-Gly-Thr-Lys-Tyr-Asn-Glu-Lys-Phe -Lys- Gly (YFNPYNHGTKYNEKFKG) and said CDR3 having the amino acid sequence Ser-Gly- Pro-Tyr-Ala-Trp-Phe-Asp-Thr (SGPYAWFDT); e.g. further comprising in sequence the hypervariable regions CDR1', CDR2' and CDR3', CDR1' having the amino acid sequence Arg-Ala-Ser-Gln-Asn-Ile-GIy-Thr~Ser-IIe-Gln (RASQNIGTSIQ), CDR2' having the amino acid sequence Ser-Ser-Ser-Glu-Ser~Ile-Ser (SSSESIS) and CDR3' having the amino acid sequence Gln-GIn-Ser-Asn-Thr-Trp~ Pro-Phe-Thr (QQSNTWPFT), e.g. a chimeric or humanised antibody, useful as a pharmaceutical.

L'invention concerne une molécule comprenant au moins un site de liaison antigène, comprenant en séquences des régions hypervariables CDR1, CDR2 et CDR3, ladite CDR1 présentant une séquence d'aminoacides Asn-Tyr-Ile-IIe-His (NYIIH), ladite CDR2 présentant une séquence d'aminoacide Tyr-Phe-Asn-Pro-Tyr-Asn-His-Gly-Thr-Lys-Tyr-Asn-Glu-Lys-Phe -Lys-Gly (YFNPYNHGTKYNEKFKG) et ladite CDR3 présentant une séquence d'aminoacide Ser-Gly-Pro-Tyr-Ala-Trp-Phe-Asp-Thr (SGPYAWFDT) ; par exemple comprenant, de plus, en séquences les régions hypervariables CDR1', CDR2' et CDR3', CDR1' présentant la séquence d'aminoacide Arg-Ala-Ser-Gln-Asn-Ile-GIy-Thr-Ser-IIe-Gln (RASQNIGTSIQ) ; CDR2' présentant la séquence d'aminoacide Ser-Ser-Ser-Glu-Ser-Ile-Ser (SSSESIS) et CDR3' présentant la séquence d'aminoacide Gln-GIn-Ser-Asn-Thr-Trp- Pro-Phe-Thr (QQSNTWPFT), par exemple un anticorps chimère ou humanisé, utilisé en tant que produit pharmaceutique.

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