Therapeutic combination of carnitine and antioxidant...

Details Therapeutic combination of carnitine and antioxidant... Therapeutic combination of carnitine and antioxidant...

C - Chemistry, Metallurgy

12

P

C12P 13/22 (2006.01) A61K 31/045 (2006.01) A61K 31/047 (2006.01) A61K 31/05 (2006.01) A61K 31/197 (2006.01) A61K 31/205 (2006.01)

Patent

CA 2531056

A composition includes acety-L-carnitine or its pharmacologically acceptable salt and a mixture of polyphenols containing hydroxytyrosol in an effective weight ratio. Carnitine can be L-carnitine, proprionyl-L-carnitine, valeryl-L- carnitine, isovaleryl-L-carnitine or mixtures thereof. The composition has a weight ratio of carnitine:hydroxytyrosol of from 100:1 to 1:10. Also disclosed is a method of preventing tissue damage caused by the presence of free radicals due to environmental pollution; of preventing brain or myocardial lesions induced by free radicals following cerebral or myocardial ischemia and reperfusion; of preventing diabetic or toxic neuropathies and metabolic disorders of glucose utilization, which includes administering the composition.

L'invention concerne une composition comprenant une acétyl-L-carnitine ou son sel pharmacologiquement acceptable et un mélange de polyphénols contenant un hydroxytyrosol selon un rapport en poids efficace. La carnitine peut être une L-carnitine, une proprionyl-L-carnitine, une valéryl-L-carnitine, une isovaléryl-L-carnitine ou des mélanges de celles-ci. Cette composition présente un rapport en poids carnitine/hydroxytyrosol compris entre 100/1 et 1/10. L'invention concerne également une méthode permettant de prévenir les dommages tissulaires dus à la présence de radicaux libres provenant de la pollution environnementale; les lésions cérébrales ou myocardiales induites par des radicaux libres après une ischémie cérébrale ou myocardiale et une reperfusion; et les neuropathies diabétiques ou toxiques et les troubles du métabolisme dus à l'utilisation du glucose. Ladite méthode consiste à administrer la composition.

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