Therapeutic combinations comprising poly(adp-ribose)...

A - Human Necessities – 61 – K

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A61K 31/55 (2006.01) A61K 31/282 (2006.01) A61K 31/4188 (2006.01) A61K 31/4745 (2006.01) A61K 31/513 (2006.01) A61K 31/519 (2006.01) A61K 31/704 (2006.01) A61K 33/24 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2581200

The invention generally relates to use of 8-fluoro-2{4- [(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6- one represented by Formula (1) as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro- 6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer.

L'invention concerne l'utilisation de 8-fluoro-2{4-[(méthylamino)méthyl]phényl}-1,3,4,5-tétrahydro-6H-azépino[5,4,3-cd]indol-6-one de formule (1) en tant qu'agent chimiosensible qui améliore l'efficacité de médicaments cytotoxiques ou la radiothérapie. L'invention concerne des combinaisons pharmaceutiques de 8-fluoro-2{4-[(méthylamino)méthyl]phényl}-1,3,4,5-tétrahydro-6H-azépino[5,4,3-cd]indol-6-one, ou un de ses sels pharmaceutiquement acceptable et au moins un agent thérapeutique supplémentaire, des kits contenant les combinaisons et des procédés d'utilisation des combinaisons pour traiter les sujets souffrant de maladies telles que le cancer.

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