Therapeutic combinations of atypical antipsychotics with...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/551 (2006.01) A61K 31/40 (2006.01) A61K 31/4178 (2006.01) A61K 31/425 (2006.01) A61K 31/437 (2006.01) A61K 31/4375 (2006.01) A61K 31/44 (2006.01) A61K 31/496 (2006.01) A61K 31/4985 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61K 31/55 (2006.01) A61K 31/554 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2556160

The present invention is directed to a pharmaceutical compositions for treating, for example, mood disorders or conditions, psychotic disorders or conditions, or a combination thereof, in a mammal such as a human, the composition comprising (a) an atypical antipsychotic, a prodrug thereof or a pharmaceutically acceptable salt of the atypical antipsychotic or prodrug thereof, (b) a corticotropin releasing factor antagonist, a prodrug thereof, or pharmaceutically acceptable salt of said corticotropin releasing factor antagonist or prodrug thereof, and optionally (c) a pharmaceutically acceptable vehicle, carrier or diluent. The present invention is also directed to a method for treating one or more disorders or conditions described in the previous sentence, the method comprising administering to a mammal in need of such treatment components (a) and (b) described in the previous sentence, wherein (a) and (b) are each optionally and independently administered together with a pharmaceutically acceptable vehicle, carrier or diluent.

L'invention concerne des compositions pharmaceutiques qui sont utilisées pour traiter, par exemple, les troubles de l'humeur, les psychoses, ou les deux, chez un mammifère tel qu'un humain. Cette composition contient: (a) un antipsychotique atypique, un promédicament de celui-ci ou un sel acceptable sur le plan pharmaceutique de l'antipsychotique atypique ou du promédicament, (b) un antagoniste du facteur de libération de la corticotrophine, un promédicament de celui-ci, ou un sel acceptable sur le plan pharmaceutique de l'antagoniste du facteur de libération de la corticotrophine ou du promédicament, et éventuellement, (c) un excipient, un véhicule ou un diluant acceptable sur le plan pharmaceutique. Par ailleurs, l'invention concerne une méthode de traitement d'un ou de plusieurs des troubles ou états pathologiques précités, qui consiste à administrer à un mammifère ayant besoin d'un tel traitement les composants (a) et (b) précités, (a) et (b) étant éventuellement administrés séparément conjointement avec un excipient, un véhicule ou un diluant.

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