Therapeutic composition for drug dependence

A - Human Necessities – 61 – K

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A61K 31/135 (2006.01) A61K 31/137 (2006.01)

Patent

CA 2171083

Provision of a drug for curing drug dependence which is less toxic and highly effective. A therapeutic composition for drug dependence which comprises as an active ingredient a phenylalkyl- amine derivative represented by the formula: Image (wherein X1 is a halogen atom, a hydroxyl group or an alkoxy group having 1 to 5 carbon atoms, X2 is a hydrogen atom, a halogen atom or an alkoxy group having 1 to 5 carbon atoms, each of R1 and R2 is an alkyl group having 1 to 7 carbon atoms, R3 is a phenyl group or a substituted phenyl group having as the substituent a halogen atom, a hydroxyl group or an alkoxy group having 1 to 5 carbon atoms, and each of m and n is an integer of 2 to 5) or a pharmaceutically acceptable salt thereof.

L'invention a pour objet un remède contre la pharmacodépendance qui est faiblement toxique et possède un excellent effet. Ce remède est constitué par une composition qui contient comme principe actif un dérivé de phénylalkylamine représenté par la formule générale (I) ou un sel pharmaceutiquement acceptable de ce dérivé. Dans la formule (I), X<1> représente halogène, hydroxy ou alcoxy C1-C5; X<2> représente hydrogène, halogène ou alcoxy C1-C5; R<1> et R<2> représentent chacun séparément alkyle C1-C7; R<3> représente phényle qui peut être substitué par halogène, hydroxy ou alcoxy C1-C5; et m et n représentent chacun un nombre entier compris entre 2 et 5.

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