Therapeutic compositions

Details Therapeutic compositions Therapeutic compositions

C - Chemistry, Metallurgy

07

D

C07D 223/16 (2006.01) A61K 31/55 (2006.01) C07D 401/02 (2006.01) C07D 401/04 (2006.01) C07D 403/02 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2137834

Benz[b]azepines of formula (I) and (II), wherein R1, R2, R3 and R4 are independently selected from hydrogen, perfluo- roalkyl, halo, nitro and cyano; R5 is selected from hydrogen and alkyl; R6 and R7 are independently selected from hydrog- en, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl and CH2Y wherein Y is selected from (CHOH)nCH2OH and (CH2)mRc whrein m is 0 to 5, n is 1 to 5 and Rc is selected from hydroxy, alkoxy, alkoxycarbo- nyl, carboxy, cycloalkyl, and NRdRe in which Rd and Re are independently selected from hydrogen and alkyl or Rd and Re, together with the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocyclic ring which optionally contains one additional heteroatom selected from nitrogen, oxygen and sulfur; or R6 and R7, together with the nitrogen at- om to which they are attached form a 5-, 6- or 7-membered heterocyclic ring which is bonded to said compound through said nitrogen atom, said heterocyclic ring optionally containing one additional heteroatom selected from nitrogen, oxygen and sulfur; R8 is selected from hydrogen, halo, alkyl which may optionally bear a substituent selected from amino, acylami- no, carboxy and carboxamido, arylalkyl and heteroarylalkyl; and wherein each aryl or heteroaryl moiety may be optionally substituted; and pharmaceutically acceptable salt thereof, are useful in treating neurological disorders. Novel compounds and processes for their preparation are also referred to as well as the use of the compounds of formula (I) and (II) and pharmaceutical compositions containing them in treating neurological disorders.

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