Therapeutic compositions

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 69/72 (2006.01) A23L 1/29 (2006.01) A23L 1/30 (2006.01) A61K 31/19 (2006.01) A61K 31/765 (2006.01) C08G 63/00 (2006.01)

Patent

CA 2283642

Compositions comprising ketone bodies and/or their metabolic precursors are provided that are suitable for administration to humans and animals and which have the properties of, interalia, (i) increasing cardiac efficiency, particularly efficiency in use of glucose, (ii) for providing energy source, particularly in diabetes and insulin resistant states and (iii) treating disorders caused by damage to brain cells, particularly by retarding or preventing brain damage in memory associated brain areas such as found in Alzheimer's and similar conditions. These compositions may be taken as nutritional aids, for example for athletes, or for the treatment of medical conditions, particularly those associated with poor cardiac efficiency, insulin resistance and neuronal damage. The invention further provides methods of treatment and novel esters and polymers for inclusion in the compositions of the invention.

L'invention concerne des compositions contenant des corps cétoniques et/ou leurs précurseurs métaboliques, qui peuvent être administrés efficacement à des humains ou à des animaux. Lesdites compositions ont la propriété, inter alia, i) de renforcer l'activité cardiaque, notamment l'efficacité dans l'utilisation du glucose; ii) de fournir une source d'énergie, en particulier dans les cas de diabète ou de résistance insulinique; et iii) de traiter des troubles dus à des lésions aux neurones du cerveau, notamment en retardant ou en empêchant les lésions dans les zones du cerveau associées à la mémoire, telles qu'on en trouve dans la maladie d'Alzheimer ou dans des pathologies similaires. Lesdites compositions peuvent être utilisées comme soutiens nutritionnels, par exemple pour les athlètes ou pour le traitement de troubles médicaux, en particulier ceux liés à l'insuffisance cardiaque, à la résistance insulinique ou à des lésions cérébrales. L'invention concerne en outre des méthodes de traitement, ainsi que de nouveaux esters et polymères pouvant entrer dans les compositions de l'invention.

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