A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 1/00 (2006.01) A61P 9/00 (2006.01) A61P 13/00 (2006.01) A61P 19/02 (2006.01) A61P 41/00 (2006.01)
Patent
CA 2371046
The present inventors have surprisingly found that the Mts-1 protein stimulates angiogenesis. In particular, the present inventors have found that Mts-1 transgenic mice developed hemangiomas and stenosis. The present inventors have also found that addition of Mts-1 proteins to the culture media increases the motility of mouse endothelial cells. Further, the present inventors have found that injection of Mts1 proteins stimulates angiogenesis in the mouse corneas. Accordingly, the present invention provides methods of enhancing angiogenesis in a subject in need thereof by administering a therapeutically effective amount of an angiogenic Mts-1 component.
Les présents inventeurs ont découvert avec grande surprise que la protéine Mts-1 stimule l'angiogenèse. Plus particulièrement, ils ont découvert que la souris transgénique Mts-1 a développé hémangiomes et sténose, et que l'ajout de protéines Mts-1 dans un milieu de culture augmente la motilité des cellules endothéliales de la souris. En outre, ils ont découvert que l'injection de protéines Mts1 stimule l'angiogenèse dans la cornée de la souris. De même, la présente invention concerne des procédés de stimulation de l'angiogenèse chez un sujet déficitaire, en lui administrant une dose efficace sur le plan thérapeutique d'un composant Mts-1 angiogénique.
Mcfadden Fincham
Research Corporation Technologies Inc.
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