Therapeutic compositions and methods for treating disease...

Details Therapeutic compositions and methods for treating disease... Therapeutic compositions and methods for treating disease...

C - Chemistry, Metallurgy

07

K

C07K 14/52 (2006.01) A61K 38/19 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2267131

There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine .alpha.1(CK.alpha.1 or cka-1), as well as Ck beta- 11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

Compositions et procédés thérapeutiques faisant appel à des molécules d'acide nucléique isolées codant un polypeptide humain de chémokine béta-11 (Ck .beta.-11) et un polypeptide humain d'inhibiteur d'adhésion leucocytaire-1 (LAI-1), précédemment appelé chémokine .alpha.1(CK.alpha.1 ou cka-1). On décrit par ailleurs les polypeptides Ck .beta.-11 et/ou LAI-1 proprement dits, des vecteurs, des cellules hôtes et des procédés de recombinaison pour leur production.

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