Therapeutic compositions and methods for treating disease...

Details Therapeutic compositions and methods for treating disease... Therapeutic compositions and methods for treating disease...

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2267193

There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine .beta.8 (CK.beta.8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-.gamma. and chemokine .beta.1(CK.beta.1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

Cette invention se rapporte à des compositions thérapeutiques et à des procédés utilisant des molécules d'acides nucléiques isolées codant un polypeptide du facteur-1 inhibiteur des précurseurs myéloïdes (MPIF-1) d'origine humaine (précédemment appelé MIP-3 et chimiokine .beta.8 (CK.beta.8 ou ckb-8)); un polypeptide du facteur inhibiteur des colonies de monocytes (M-CIF) d'origine humaine (précédemment appelé MIP1-.gamma. et chimiokine .beta.1(CK.beta.1 ou ckb-1)), et une protéine inhibant la migration des macrophages (MIP-4). L'invention se rapporte également aux polypeptides de MPIF-1, M-CIF et/ou MIP-4 ainsi qu'à des vecteurs, cellules hôtes et procédés de recombinaison destinés à la production desdits polypeptides.

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