Therapeutic compositions and methods for treating disease...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/435 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2388942

Human chemokine .beta.-6 agonist and antagonist polypeptides and DNA encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. The chemokine .beta.-6 antagonists of the present invention may be employed to treat rheumatoid arthritis, lung inflammation, allergy, asthma , infectious diseases and to prevent inflammation and atherosclerosis. The chemokine .beta.-6 agonists and antagonists may be employed to myeloprotect patients undergoing therapy such as chemotherapy or radiation therapy.

La présente invention concerne des polypeptides agonistes et antagonistes de chimiokine .beta.-6 humaine, de l'ADN codant pour ces polypeptides et une procédure permettant de produire ces polypeptides par des techniques de recombinaison. Ces antagonistes de chimiokine .beta.-6 peuvent être utilisés pour traiter la polyarthrite rhumatoïde, les inflammations pulmonaires, les allergies, l'asthme, des maladies infectieuses et pour prévenir les inflammations et l'artériosclérose. Ces antagonistes et agonistes de chimiokine .beta.-6 peuvent être utilisés pour une protection myéloïde de patients qui entreprennent une thérapie telle qu'une chimiothérapie ou qu'une radiothérapie.

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