A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/19 (2006.01) A61K 31/29 (2006.01) A61K 31/496 (2006.01) A61K 31/555 (2006.01) A61P 31/12 (2006.01) A61P 33/02 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2459793
In one embodiment, a therapeutic composition containing a pentavalent antimonial is provided. The pentavalent antimonial can be sodium stibogluconate, levamisole, ketocobazole, and pentamidine and biological equivalents of said compounds. Additionally, pentavalent antimonials that can be used in accordance with the present invention may be any such compounds which are anti-leishmaniasis agents. The therapeutic composition of this embodiment contains an effective amount of pentavalent antimonial that can be used in treating infectious diseases. The types of diseases that can be treated with the present invention include, but are not limited to, the following: diseases associated with PTPase activity, immune deficiency, cancer, infections (such as viral infections), hepatitis B, and hepatitis C. The types of cancers that the present embodiment can be used to treat include those such as lymphoma, multiple myeloma, leukemia, melanoma, prostate cancer, breast cancer, renal cancer, bladder cancer. The therapeutic composition enhances cytokine activity. The therapeutic composition may include a cytokine, such as interferon .alpha., interferon .beta., interferon .gamma., or granulocyte/macrophage colony stimulating factor.
Dans un mode de réalisation, cette invention concerne une composition thérapeutique comprenant un antimonié pentavalent. Cet antimonié pentavalent peut être du sodium stiboglutamate, du levamisole, du ketocobazole ou de la pentamidine ainsi que des équivalents biologiques desdits composés,. De plus, les antimoniés pentavalents susceptibles d'être utilisés d'après la présente invention peuvent englober n'importe quel composé agissant contre la leishmainiose. La composition thérapeutique de cette invention renferme une dose efficace d'un antimonié pentavalent pouvant être utilisé dans le traitement des maladies infectieuses. Peuvent être traitées avec les compositions de l'invention les maladies suivantes, notamment : maladies associées à l'activité de protéines tyrosines phosphatases, immunodéficience, cancer, infections (telles qu'infections virales), hépatite B et hépatite C. Cancers pouvant être traités avec les compositions de l'invention : lymphome, myélome multiple, leucémie, mélanome, cancers de la prostate, du sein, du rein, de la vessie. >Ces compositions thérapeutiques favorisent l'activité de la cytokine. La composition thérapeutique peut renfermer une cytokine, telle que l'interféron alpha , l'interféron beta , l'interféron gamma , ou un facteur de stimulation des colonies de granulocytes/macrophage.
Smart & Biggar
The Cleveland Clinic Foundation
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