Therapeutic compositions for treatment of cancer

Details Therapeutic compositions for treatment of cancer Therapeutic compositions for treatment of cancer

A - Human Necessities

61

K

A61K 38/28 (2006.01) A61K 35/14 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/17 (2006.01) A61K 38/27 (2006.01) A61K 38/30 (2006.01) A61K 38/43 (2006.01) A61K 38/46 (2006.01) A61K 38/51 (2006.01) A61K 47/48 (2006.01) A61M 1/14 (2006.01) A61M 1/16 (2006.01) A61M 1/34 (2006.01) A61M 1/38 (2006.01) A61M 5/165 (2006.01)

Patent

CA 2263338

Therapeutic compositions, apparatus, and method for the treatment of tumors by systemic deprivation of an essential amino acid, preferably of arginine, by extracorporeal treatment of the patient's blood characterized by molecular exchange between the blood and a dialyzing fluid which contains most of the essential low-molecular substances found in blood plasma with the exception of at least one of the essential amino acids. The release of muscular protein amino acids can be limited by use of an insulin/glucose clamp. The treatment process can be used in conjunction with chemotherapy.

L'invention a trait à des compositions thérapeutiques, un appareillage, et un procédé destinés au traitement de tumeurs par privation systémique d'un acide aminé essentiel, de préférence l'arginine, au moyen d'un traitement extracorporel du sang du patient, caractérisé par un échange moléculaire entre le sang et un fluide dialysé contenant la plupart des substances essentielles de bas poids moléculaire que l'on trouve dans le plasma sanguin, à l'exception d'au moins un des acides aminés essentiels. La libération d'acides aminés de protéines musculaires peut être limitée par l'utilisation d'un contrôle insuline/glucose. Ce procédé de traitement peut être utilisé conjointement avec une chimiothérapie.

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