Therapeutic compound - fatty acid conjugates

Details Therapeutic compound - fatty acid conjugates Therapeutic compound - fatty acid conjugates

C - Chemistry, Metallurgy

07

K

C07K 17/06 (2006.01) A61K 31/23 (2006.01) A61K 31/485 (2006.01) A61K 31/505 (2006.01) A61K 31/57 (2006.01) A61K 31/70 (2006.01) A61K 38/13 (2006.01) A61K 47/48 (2006.01) C07C 237/20 (2006.01) C07C 237/22 (2006.01) C07D 475/08 (2006.01) C07D 489/02 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01) C07J 41/00 (2006.01) C07J 43/00 (2006.01) C07K 5/00 (2006.01) C07K 5/065 (2006.01) C07K 7/06 (2006.01) C07K 7/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2210500

The present invention relates to a range of therapeutic compounds conjugated to one to three acyl groups derived from fatty acids. The therapeutic compounds are selected from the following group: 1) the corticosterone family of drugs; 2) opioids and opioid antagonists; 3) antiviral nucleosides, such as AZT; 4) cyclosporins and related cyclopeptides; 5) folate antagonists including methotrexate, folic acid and folic acid analogues; 6) catecholamine precursors, such as DOPA and Dopamine, and catecholamines, such as adrenaline and noradrenaline and derivatives; and 7) alkylating agents containing a carboxylic acid group, such as chlorambucil and melphalan. The therapeutic compound is conjugated to the fatty acid(s) by a link which includes a tromethamine or ethanolamine derivative. In particular the present invention relates to altering the pharmacokinetic profile and mode of delivery of these therapeutic compounds by conjugating them to one, two or three acyl derivatives of fatty acids.

La présente invention concerne une gamme de composés thérapeutiques conjugués à un, deux ou trois groupes acyles dérivés d'acides gras. Les composés thérapeutiques sont choisis parmi les groupes suivants: 1) médicaments de la famille de la corticostérone; 2) opioïdes et antagonistes des opioïdes; 3) nucléosides antiviraux tels que l'AZT; 4) cyclosporines et cyclopeptides similaires; 5) antagonistes des folates tels que le méthotrexate, l'acide folique et les analogues de l'acide folique; 6) précurseurs de catécholamines, tels que la DOPA et la dopamine, ainsi que des catécholamines telles que l'adrénaline, la noradrénaline et leurs dérivés; et 7) agents d'alkylation contenant un groupe acide carboxylique, tels que le chlorambucile et le melphalan. Ces composés thérapeutiques sont conjugués à l'acide (ou aux acides) gras par une liaison comprenant un dérivé de trométhamine ou d'éthanolamine. En particulier, la présente invention permet de moduler le profil pharmacocinétique et le profil d'administration de ces composés thérapeutiques en les conjuguant à un, deux ou trois groupes acyle dérivés d'acides gras.

Affiliated with

Also associated with

Rating

Therapeutic compound - fatty acid conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic compound - fatty acid conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic compound - fatty acid conjugates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1496284