C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/34 (2006.01) A61K 31/4178 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2665818
The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabalizers and as anti-proliferative agents.
La présente invention concerne des composés de formule I : où A, B, D, E, R1, R2, R3, R4, R5, X et ----- prennent l'une quelconque des valeurs définies dans la présente invention, ainsi que leurs sels. Les composés sont actifs en tant que stabilisants d'ADN G-quadruplex et en tant qu'agents antiproliférants.
Lavoie Edmond J.
Liu Leroy F.
Rice Joseph E.
Rutgers The State University Of New Jersey
Smart & Biggar
University Of Medicine And Dentistry Of New Jersey
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